Study of the Interactive Effect between Tylosin Tartrate and Colistin for its Use in the Therapy and Prevention of Poultry Diseases in Veterinary Medicine

The pharmacological interaction of antibiotic combinations tylosin and colistin was studied. For this purpose, an in vitro challenge method used. results were used to calculate their using the graphic representation known as ISOBOLOGRAM. pure salts tartrate sulfate obtained from manufacturer product, Laboratorios Ecozoo SA de CV Mexico. bioassay agar wells quantify results, following criteria used: A synergistic effect defined when real/theoretical (SMF) greater than 1. additive SMF equal area between antagonism zone indifference. When studying it observed that best combination 3 2 : 4 (tylosin respectively). It cocluded with exerts a can be recommended for oral administration poultry treatment infections by disease producing germs sensitive formula.